A Comparative Study of HAT Reactivity in Bioinspired Dicopper Complexes and Copper-doped Dodecavanadates (A02 – A03 – B03)

This project bridges methodical investigations of biological PCET in bioinspired complexes (A03 and B03) with studies on polyoxometalates as molecular PCET mediators (A02). Building on mechanistic insights from the Meyer group on hydrogen atom abstraction (HAT) thermodynamics in pyrazolate-based μ-1,2-peroxo dicopper(II) complexes[1-2] and iron-nickel hydrogenases, we transfer established methods of project B03 and A03 and analytical approaches to copper-doped dodecavanadates (CuV12).